Some hair growth supplements have a credibility problem. A lot are loaded with biotin—a single ingredient at mega-doses with no real clinical data for hair growth. Xtressé Hair Growth Gummies® were built in direct opposition to that formula.
Founded by dermatologists and hair restoration experts who, as the brand puts it, “were tired of seeing the same thing—products full of promises and empty on science,” Xtressé went back to the key causes of hair loss and mapped what actually stops shedding and drives growth. The result: a biotin-free gummy that earned the NewBeauty 100 Whatʼs Next in Beauty award in 2025 and our Best Hair Growth Supplement distinction in 2026. Here is exactly why it won.
The Biotin-Free Bet That Paid Off
The decision to go biotin-free is one of the most significant features of Xtressé, and it is not a gimmick. While biotin deficiency is actually quite rare, high-dose biotin supplements are everywhere in the hair care space—and research suggests they can interfere with thyroid and cardiac lab results, creating false readings. Xtresseʼs dermatologist founders chose to skip it entirely and focus on eight clinically backed bioactives that support healthy follicles and the normal hair growth cycle.
The Eight Ingredients and What They Actually Do
The X3-BioActive Blend™ targets five factors that contribute to hair thinning—oxidative and environmental stress, systemic and localized inflammation , cellular aging, and nutrient deficiency—through a coordinated stack of ingredients, not a single hero molecule.
NAD+
A naturally occurring coenzyme involved in cellular energy metabolism. Because NAD+ levels naturally decline with age, Xtressé includes NAD+ to help support healthy cellular function and healthy hair.
Rich in naturally occurring phytosterols and antioxidants, pumpkin seed extract helps support healthy hair follicles and hair density. Published clinical studies have evaluated pumpkin seed extract for its role in supporting healthy hair.
Taurine
Protects hair follicles and promotes follicle survival during the growth phase. Taurine is found naturally in the dermal papilla cells at the base of each follicle and plays a role in keeping those cells viable.
Saw Palmetto
Naturally occurring amino acid supports healthy cellular function and healthy hair follicles as part of a balanced hair health formula.
Ashwagandha
Adaptogenic botanical that helps support a healthy response to occasional stress and overall wellness as part of a comprehensive hair health formula.
Rich in naturally occurring silica to help support healthy hair strength, texture, and appearance.
Rich in naturally occurring antioxidant compounds that help support scalp health and overall hair wellness.
Clinically studied to support healthy hair growth and healthy hair follicles as part of a comprehensive hair health formula.
What a Derm Over 50 Actually Uses
Perhaps the most telling endorsement comes from Louisville, KY dermatologist Tami Buss Cassis, MD—who uses Xtressé herself and recommends it to her patients. “Just like with our skin, hair changes as we get into our 50s,” she says. “Itʼs a thing and, unfortunately, we havenʼt always been so great talking openly about it.” She points specifically to the formulation as a differentiator: “We have made serious progress in understanding great vitamins that do not contain higher levels of biotin to help men and women with hair growth. My favorite is Xtressé. It is two easy gummies a day. Within six weeks, you will see a difference in the overall quality of your hair.”
Dr. Buss Cassis also flags a hair loss trigger that often catches patients off guard: anesthesia. “When you have a procedure that requires anesthesia, it is very possible you will notice an increase in shedding three to six months after the procedure,” she says—a condition known as telogen effluvium, or stress-related shedding. Itʼs exactly the kind of systemic, cortisol-driven hair disruption that Xtresseʼs ashwagandha inclusion is designed to address. As Dr. Buss Cassis puts it: “Telogen effluvium is common but correctable. The days of worrying about losing all your hair are over.”
The Clinical Results
The numbers are among the most compelling in the supplement category. In an ongoing clinical study of women with self-perceived thinning hair——82 percent of participants saw measurable improvement within four months¹. Nearly 200,000 customers are now using the product, and the brand reports meaningful before-and-after results across a wide age range, from a 28-year-old with early thinning to a 65-year-old with more advanced loss.
What Sets It Apart From Everything Else on the Market
Beyond the ingredient list, a few things distinguish Xtressé from the crowded supplement field:
- It is sugar-free, soy-free, shellfish-free, gluten-free, hormone-free, and vegetarian—a clean formula without the usual tradeoffs.
- It was developed by an in-house team of dermatologists and hair restoration specialists, not by a marketing team working backward from a trend.
- Every ingredient is dosed at or below the recommended daily value, making long-term, continuous use low-risk.
- It fits into a broader system, including the FR Concentrate Serum and in-office Xvie XO treatments, for those who want a complete, layered approach.
The Xtressé Hair Growth Gummies are available at Dermatology practices throughout the country and available on xtresse.com.
¹Based on an interim report of a 4-month, open-label, single-group study of 60 women aged 28 to 65 yrs with self-perceived thinning hair who took two Xtressé Gummies daily. Visible improvement was measured using Hair Density Changes Measured by SOCAi, and Canfield HairMetrix Phototrichogram Analysis; 9 of 11 participants met the improvement criterion. The study did not include a placebo control. Results have not yet been reported. Individual results may vary. ClinicalTrials.gov Identifier: NCT07224555.
The product and statements herein have not been evaluated by the Food and Drug Administration (FDA). Xtresse™ products are not intended to diagnose, treat, cure or prevent any disease or condition. Xtressé is a registered trademark of Restore Biologics Holdings, LLC. All rights reserved ©2024 Restore Biologics Holdings, LLC dba xtressé.
