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Regenerative aesthetics is an exciting area of medicine\u2014not only because of what it can do for the skin, but because it is constantly in flux. Every few months brings a buzzy serum or new indication for an injectable that is nothing less than game-changing. We\u2019ve cycled through the benefits of PRP, exosomes, growth factors, PDRN\u2014and now, platelet-derived growth factor. PDGF is making waves in dermatology offices as an adjunct to popular in-office treatments.<\/p>\n
Ahead, we spoke with dermatologists about PDGF\u2019s growing popularity with microneedling, and why you might want to consider pairing it with your next in-office session.<\/p>\n<\/div>\n
\u201cPDGF is a powerful regenerative protein naturally found in the body that plays a key role in healing and skin renewal. In skin care, it\u2019s typically lab-engineered and formulated into lightweight serums designed to absorb easily into the skin,\u201d explains Miami dermatologist Anna Chacon, MD. PDGF essentially acts as a messenger, communicating with cells involved in regeneration and helping to orchestrate the healing response. It helps to stimulate collagen production, improve skin elasticity and support overall skin repair. Expect smoother, firmer and more resilient skin over time.<\/p>\n
New York dermatologist Dr. Shereen Teymour says the PDGF that is generating the most buzz right now in aesthetics is recombinant human PDGF-BB, meaning it is manufactured in a controlled environment, rather than it being extracted from a patient\u2019s blood. \u201cWith ariessence pure PDGF+, for example, the PDGF is combined with a hyaluronic acid-based solution before topical application. The result is essentially a lightweight serum that can be applied directly to the skin after a procedure,\u201d she explains.<\/p>\n
Ariessence pure PDGF+, marketed for topical cosmetic use, is currently garnering the majority of attention. \u201cInjection of this particular product is not FDA-approved, and the manufacturer specifically states that it is not intended for administration by injection,\u201d says Dr. Teymour. She further explains that this type of PDGF should not be confused with other FDA-approved recombinant PDGF products intended to be injected for orthopedic use, \u201cwhich is why PDGF itself has such an interesting history, but again, this should not be confused with approval to inject a topical cosmetic PDGF product into the face.\u201d<\/p>\n
PRP and PRF are derived from a patient\u2019s own blood and can vary in composition, whereas PDGF products are more standardized, but are designed to mimic some of the same regenerative benefits. \u201c[PRP and PRF] contain platelets and a mixture of multiple growth factors and signaling molecules, including naturally occurring PDGF,\u201d says Dr. Teymour. Recombinant PDGF, on the other hand, is much more targeted. \u201cYou\u2019re delivering a highly purified, standardized version of one specific signaling protein rather than the variable mixture found in someone\u2019s own blood,\u201d she explains.<\/p>\n
PDGF is also often compared with exosome products because both fall under the broader umbrella of regenerative aesthetics, but remain biologically different. \u201cExosomes are extracellular vesicles that can carry numerous proteins, lipids and signaling molecules; PDGF is a defined growth factor,\u201d says Dr. Teymour.<\/p>\n
Microneedling creates thousands of controlled micro-injuries in the skin, helping to stimulate the body\u2019s natural wound-healing and collagen remodeling process. The temporary microchannels created in the skin after microneedling make it an ideal time to apply a topical regenerative product like PDGF. \u201cRegenerative treatments and microneedling are such a natural pairing. They\u2019re both centered around encouraging repair and remodeling,\u201d says Miami dermatologist Dr. Deborah Longwill.<\/p>\n
\u201cI consider the combination of the two as a synergistic approach to skin regeneration: the microneedling provides the initial stimulus for repair and collagen production, while PDGF provides additional signaling to support that regenerative environment,\u201d says Dr. Teymour. \u201cWe\u2019re not simply applying another serum on top of intact skin, rather, we\u2019re strategically pairing it with a procedure designed to initiate skin remodeling.\u201d<\/p>\n
After PDGF is applied topically immediately after microneedling (or even a resurfacing laser), it may be continued to be applied topically at home depending on the protocol. Because collagen remodeling takes time, dermatologists usually recommend a series of treatments spaced about four to six weeks apart, with results continuing to improve over time.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"
Regenerative aesthetics is an exciting area of medicine […]<\/p>\n","protected":false},"author":1,"featured_media":2663,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[55],"tags":[],"_links":{"self":[{"href":"https:\/\/nichebeaty.com\/index.php\/wp-json\/wp\/v2\/posts\/2662"}],"collection":[{"href":"https:\/\/nichebeaty.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nichebeaty.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nichebeaty.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nichebeaty.com\/index.php\/wp-json\/wp\/v2\/comments?post=2662"}],"version-history":[{"count":0,"href":"https:\/\/nichebeaty.com\/index.php\/wp-json\/wp\/v2\/posts\/2662\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nichebeaty.com\/index.php\/wp-json\/wp\/v2\/media\/2663"}],"wp:attachment":[{"href":"https:\/\/nichebeaty.com\/index.php\/wp-json\/wp\/v2\/media?parent=2662"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nichebeaty.com\/index.php\/wp-json\/wp\/v2\/categories?post=2662"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nichebeaty.com\/index.php\/wp-json\/wp\/v2\/tags?post=2662"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}